August 29, 2025

Richard A Lang, PhD
Professor and Endowed Chair
University of Cincinnati Department of Ophthalmology

Hosted by: Ignacio Provencio, PhD

Opsins 3, 4 and 5, in development, homeostasis and disease, inside and outside the eye

The non-visual opsins OPN3 (encephalopsin), OPN4 (melanopsin), and OPN5 (neuropsin) are short-wavelength photon detectors with crucial roles in mammalian physiology. We have learned that all three opsins have important roles inside and outside the eye, in guiding developmental processes and regulating energy homeostasis in adults.